“There have been a lot of online videos and photos touting the fact that when left out for an extended period of time, a McDonald’s hamburger does not rot and that this is because they are laden with chemicals. The reality is that McDonald’s hamburgers, french fries and chicken are like all foods, and do rot if kept under certain conditions. 

Essentially, the microbes that cause rotting are a lot like ourselves, in that they need water, nutrients, warmth and time to grow. If we take one or more of these elements away, then microbes cannot grow or spoil food. 

In the example of a McDonald’s hamburger, the patty loses water in the form of steam during the cooking process. The bun, of course, is made out of bread. Toasting it reduces the amount of moisture. This means that after preparation, the hamburger is fairly dry. When left out open in the room, there is further water loss as the humidity within most buildings is around 40%. So in the absence of moisture or high humidity, the hamburger simply dries out, rather than rot.”

Source: Why McDonald’s Hamburgers Don’t Rot – Business Insider